[HTML][HTML] Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts

MJ Twiner, N Rehmann, P Hess, GJ Doucette - Marine drugs, 2008 - mdpi.com
Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species
and have been associated with severe gastrointestinal human intoxications since 1995. This …

Biotechnological and pharmacological applications of biotoxins and other bioactive molecules from dinoflagellates

J Assunção, AC Guedes, FX Malcata - Marine Drugs, 2017 - mdpi.com
The long-lasting interest in bioactive molecules (namely toxins) produced by (microalga)
dinoflagellates has risen in recent years. Exhibiting wide diversity and complexity, said …

Phytoplankton toxins and their potential therapeutic applications: a journey toward the quest for potent pharmaceuticals

B Pradhan, JS Ki - Marine Drugs, 2022 - mdpi.com
Phytoplankton are prominent organisms that contain numerous bioactive substances and
secondary metabolites, including toxins, which can be valuable to pharmaceutical …

Global gene expression profiling in larval zebrafish exposed to microcystin-LR and microcystis reveals endocrine disrupting effects of cyanobacteria

ED Rogers, TB Henry, MJ Twiner… - … science & technology, 2011 - ACS Publications
Microcystis blooms occur worldwide and threaten aquatic ecosystems and human health.
Sublethal effects on early developmental stages of fish are largely unknown, and research …

Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations

A Furey, S O'Doherty, K O'Callaghan, M Lehane… - Toxicon, 2010 - Elsevier
It has been almost a decade since a previously unknown human toxic syndrome,
azaspiracid poisoning (AZP), emerged as the cause of severe gastrointestinal illness in …

Identification of Azadinium species and a new azaspiracid from Azadinium poporum in Puget Sound, Washington State, USA

JH Kim, U Tillmann, NG Adams, B Krock, WL Stutts… - Harmful Algae, 2017 - Elsevier
The identification of a new suite of toxins, called azaspiracids (AZA), as the cause of human
illnesses after the consumption of shellfish from the Irish west coast in 1995, resulted in …

Derivation of toxicity equivalency factors for marine biotoxins associated with Bivalve Molluscs

LM Botana, P Hess, R Munday, A Nathalie… - Trends in Food Science …, 2017 - Elsevier
Background Seafood toxins pose an important risk to human health, and maximum levels
were imposed by regulatory authorities throughout the world. Several toxin groups are …

Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels

MJ Twiner, GJ Doucette, A Rasky… - Chemical research in …, 2012 - ACS Publications
Azaspiracids (AZA) are polyether marine dinoflagellate toxins that accumulate in shellfish
and represent an emerging human health risk. Although human exposure is primarily …

Phycotoxins: chemistry, mechanisms of action and shellfish poisoning

GP Rossini, P Hess - … , Clinical and Environmental Toxicology: Volume 2 …, 2010 - Springer
Phycotoxins are natural metabolites produced by micro-algae. Through accumulation in the
food chain, these toxins may concentrate in different marine organisms, including filter …

[PDF][PDF] PANEL MEMBERS

J Alexander, D Benford, A Cockburn… - Journal …, 2008 - bezpecnostpotravin.cz
SUMMARY Theobromine (3, 7-dihydro-3, 7-dimethyl-H-purine-2, 6-dione) is a colourless
and odourless 3, 7-dimethylxanthine with a slightly bitter taste naturally present in the cacao …