Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

How mitochondrial DNA mutations clonally expand in an individual cell is a question that
has perplexed mitochondrial biologists for decades. A growing body of literature indicates …

Background Modern sequencing technologies should make the assembly of the relatively
small mitochondrial genomes an easy undertaking. However, few tools exist that address …

Most heritable information in eukaryotic cells is encoded in the nuclear genome, with
inheritance patterns following classic Mendelian segregation. Genomes residing in the …

Mutations spawn genetic variation which, in turn, fuels evolution. Hence, experimental
investigations into the rate and fitness effects of spontaneous mutations are central to the …

The fate of new mitochondrial and plastid mutations depends on their ability to persist and
spread among the numerous organellar genome copies within a cell (heteroplasmy). The …

Background Elevated temperatures can cause physiological, biochemical, and molecular
responses in plants that can greatly affect their growth and development. Mutations are the …

Mutations are the origin of genetic diversity, and the mutation rate is a fundamental
parameter to understand all aspects of molecular evolution. The combination of mutation …

Gene duplication and deletion are pivotal processes sha** the structural and functional
repertoire of genomes, with implications for disease, adaptation, and evolution. We …

Steroid sulfatase (STS) deficiency is responsible for X-linked ichthyosis (XLI), a genetic
disorder characterized by rough and dry skin caused by excessive keratinization. The …