Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread
metabolic disease globally, and its associated complications including insulin resistance …

Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …

Mitochondria use hydrogen peroxide (H 2 O 2) as a mitokine for cell communication. H 2 O 2
output for signaling depends on its rate of production and degradation, both of which are …

Background Modern lifestyles, especially high-caloric intake and physical inactivity,
contribute to the increased prevalence of non-alcoholic fatty liver disease (NAFLD), which …

Liver steatosis, inflammation, and variable degrees of fibrosis are the pathological
manifestations of nonalcoholic steatohepatitis (NASH), an aggressive presentation of the …

Proinflammatory macrophages are key in the development of obesity. In addition, reactive
oxygen species (ROS), which activate the Fgr tyrosine kinase, also contribute to obesity …

Mitochondria are double-membrane organelles that play a role in ATP synthesis, calcium
homeostasis, oxidation-reduction status, apoptosis, and inflammation. Several human …