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Emerging role of dipeptidyl peptidase-4 in autoimmune disease
J Huang, X Liu, Y Wei, X Li, S Gao, L Dong… - Frontiers in …, 2022 - frontiersin.org
Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an
ubiquitously expressed protease presented as either a membrane-bound or soluble form …
ubiquitously expressed protease presented as either a membrane-bound or soluble form …
Combination of vitamin D and dipeptidyl peptidase-4 inhibitors (VIDPP-4i) as an immunomodulation therapy for autoimmune diabetes
Abstract Type 1 diabetes (T1D) and latent autoimmune diabetes in adults (LADA) represent
the most common types of autoimmune diabetes and are characterized by different age of …
the most common types of autoimmune diabetes and are characterized by different age of …
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by insulin-
producing pancreatic β-cell destruction and hyperglycemia. While monocytes and NOD-like …
producing pancreatic β-cell destruction and hyperglycemia. While monocytes and NOD-like …
Characterization of DPP-IV Inhibitory Peptides Using an In Vitro Cell Culture Model of the Intestine
R **, J Shang, X Teng, L Zhang, M Liao… - Journal of Agricultural …, 2021 - ACS Publications
Here, we characterize the activities of two depeptidyl peptidase-IV (DPP-IV) inhibitory
peptides, VLATSGPG and LDKVFER, using the Caco-2 monolayer model for the intestine …
peptides, VLATSGPG and LDKVFER, using the Caco-2 monolayer model for the intestine …
Release of dipeptidyl peptidase IV inhibitory peptides from salmon (Salmo salar) skin collagen based on digestion–intestinal absorption in vitro
J Ritian, X Teng, M Liao, L Zhang, Z Wei… - … Journal of Food …, 2021 - academic.oup.com
Inhibition of dipeptidyl peptidase IV (DPP-IV) was considered to be a crucial target for type 2
diabetes, and food-derived peptides were superior source of DPP-IV inhibitory peptides. The …
diabetes, and food-derived peptides were superior source of DPP-IV inhibitory peptides. The …
Klotho ameliorates cellular inflammation via suppression of cytokine release and upregulation of miR-29a in the PBMCs of diagnosed Alzheimer's disease patients
Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by
neural inflammation and oxidative stress. In the current study, the protective effects of klotho …
neural inflammation and oxidative stress. In the current study, the protective effects of klotho …
Emerging roles of dipeptidyl peptidase-4 inhibitors in delaying the progression of type 1 diabetes mellitus
J Gurgel Penaforte-Saboia, CEB Couri… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Type 1 diabetes mellitus (T1DM) results from the immune cell-mediated destruction of
functional pancreatic β-cells. In the presymptomatic period, T1DM is characterized by the …
functional pancreatic β-cells. In the presymptomatic period, T1DM is characterized by the …
Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice
X He, W Li, Y **e, Y Zhao - International immunopharmacology, 2020 - Elsevier
Abstract Dipeptidyl-peptidase 4 (DPP-4) inhibitor (sitagliptin) is a novel anti-hyperglycemia
drug in the treatment of type 2 diabetes. However, its potential in type 1 diabetes is still …
drug in the treatment of type 2 diabetes. However, its potential in type 1 diabetes is still …
Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors
Abstract DPP4 (Dipeptidyl-peptidase 4) a versatile protease, emerges as a prominent player
in soluble and membrane-bound forms. Its heightened expression has been intimately …
in soluble and membrane-bound forms. Its heightened expression has been intimately …