Respiratory syncytial virus
A Jha, H Jarvis, C Fraser… - SARS, MERS and other …, 2016 - library.oapen.org
Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million
cases in children younger than 5 years, with 10% requiring hospital admission and up to …
cases in children younger than 5 years, with 10% requiring hospital admission and up to …
RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection
A Jozwik, MS Habibi, A Paras, J Zhu, A Guvenel… - Nature …, 2015 - nature.com
In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination
but their importance in man has not been determined. Here, using experimental human …
but their importance in man has not been determined. Here, using experimental human …
Impaired antibody-mediated protection and defective IgA B-cell memory in experimental infection of adults with respiratory syncytial virus
Rationale: Despite relative antigenic stability, respiratory syncytial virus (RSV) reinfects
throughout life. After more than 40 years of research, no effective human vaccine exists and …
throughout life. After more than 40 years of research, no effective human vaccine exists and …
Protective and harmful immunity to RSV infection
Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …
Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients
Background Viral infections of the respiratory tract represent a major global health concern.
Co-infection with bacteria may contribute to severe disease and increased mortality in …
Co-infection with bacteria may contribute to severe disease and increased mortality in …
Immunity to RSV in early-life
L Lambert, AM Sagfors, PJM Openshaw… - Frontiers in …, 2014 - frontiersin.org
Respiratory Syncytial Virus (RSV) is the commonest cause of severe respiratory infection in
infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each …
infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each …
Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for develo** vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Transcriptional profiles and host-response biomarkers are used increasingly to investigate
the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA …
the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA …
[HTML][HTML] Does respiratory syncytial virus lower respiratory illness in early life cause recurrent wheeze of early childhood and asthma? Critical review of the evidence …
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection (LRTI)
and hospitalization in infants and children globally. Many observational studies have found …
and hospitalization in infants and children globally. Many observational studies have found …
Antiviral B cell and T cell immunity in the lungs
Respiratory viruses are frequent causes of repeated common colds, bronchitis and
pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those …
pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those …