The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …

Although meningiomas are the most common intracranial tumours, the level of evidence to
provide recommendations for the diagnosis and treatment of meningiomas is low compared …

Abstract Treatment of the tumor and dural margin with surgery and sometimes radiation are
cornerstones of therapy for meningioma. Molecular classifications have provided insights …

Background Meningiomas are the most common primary intracranial tumor in adults.
Clinical care is currently guided by the World Health Organization (WHO) grade assigned to …

A minority of headache patients have a secondary headache disorder. The medical
literature presents and promotes red flags to increase the likelihood of identifying a …

Unruptured intracranial aneurysms (UIAs) are commonly acquired vascular lesions that form
an outpouching of the arterial wall due to wall thinning. The prevalence of UIAs in the …

Saccular unruptured intracranial aneurysms (UIAs) have a prevalence of 3% in the adult
population, and are being increasingly detected because of improved quality and higher …

Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and
a largely untreatable cause of intracerebral haemorrhage and contributor to age-related …

Although CNS tumors are rare, they are a significant cause of cancer morbidity and mortality,
especially in children and young adults where they respectively account for approximately …

Purpose—The aim of this updated statement is to provide comprehensive and evidence-
based recommendations for management of patients with unruptured intracranial …