The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
[HTML][HTML] Progress and perspectives on targeting nanoparticles for brain drug delivery
H Gao - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …
it is a challenge to treat central nervous system disorders pharmacologically. The …
[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
miR-181b targets semaphorin 3A to mediate TGF-β–induced endothelial-mesenchymal transition related to atrial fibrillation
Atrial fibrosis is an essential contributor to atrial fibrillation (AF). It remains unclear whether
atrial endocardial endothelial cells (AEECs) that undergo endothelial-mesenchymal …
atrial endocardial endothelial cells (AEECs) that undergo endothelial-mesenchymal …
[HTML][HTML] Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity
GJ Prud'homme, Y Glinka - Oncotarget, 2012 - ncbi.nlm.nih.gov
The neuropilins (Nrps) are multifunctional proteins involved in development, immunity and
cancer. Neuropilin-1 (Nrp1), or its homologue neuropilin-2 (Nrp2), are coreceptors that …
cancer. Neuropilin-1 (Nrp1), or its homologue neuropilin-2 (Nrp2), are coreceptors that …
Classical and alternative receptors for SARS‐CoV‐2 therapeutic strategy
Understanding the molecules that are essential for severe acute respiratory syndrome
coronavirus‐2 (SARS‐CoV‐2) entry can provide insights into viral infection and …
coronavirus‐2 (SARS‐CoV‐2) entry can provide insights into viral infection and …
Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance
Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system
development by regulating angiogenesis and axon guidance cues. Several published …
development by regulating angiogenesis and axon guidance cues. Several published …
The role of neuropilin-1 (NRP-1) in SARS-CoV-2 infection
M Gudowska-Sawczuk, B Mroczko - Journal of Clinical Medicine, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovered in 2019, is
responsible for the global coronavirus disease 19 (COVID-19) pandemic. The main protein …
responsible for the global coronavirus disease 19 (COVID-19) pandemic. The main protein …
TGF‐β superfamily co‐receptors in cancer
Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …
Peptide-functionalized phase-transformation nanoparticles for low intensity focused ultrasound-assisted tumor imaging and therapy
LL Zhu, HY Zhao, ZY Zhou, YH **a, ZG Wang… - Nano Letters, 2018 - ACS Publications
In this study, we successfully developed novel tumor homing-penetrating peptide-
functionalized drug-loaded phase-transformation nanoparticles (tLyP-1-10-HCPT-PFP NPs) …
functionalized drug-loaded phase-transformation nanoparticles (tLyP-1-10-HCPT-PFP NPs) …