Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

Defining and combating antibiotic resistance from One Health and Global Health perspectives

S Hernando-Amado, TM Coque, F Baquero… - Nature …, 2019 - nature.com
Several interconnected human, animal and environmental habitats can contribute to the
emergence, evolution and spread of antibiotic resistance, and the health of these contiguous …

[HTML][HTML] The spread of antibiotic resistance to humans and potential protection strategies

D Ding, B Wang, X Zhang, J Zhang, H Zhang… - Ecotoxicology and …, 2023 - Elsevier
Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles

R Wang, S Cao, MEH Bashir, LA Hesser, Y Su… - Nature Biomedical …, 2023 - nature.com
The microbiome modulates host immunity and aids the maintenance of tolerance in the gut,
where microbial and food-derived antigens are abundant. Yet modern dietary factors and …

Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement

MH Woodworth, RE Conrad, M Haldopoulos… - Science translational …, 2023 - science.org
Multidrug-resistant organism (MDRO) colonization is a fundamental challenge in
antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation …

Commensal consortia decolonize Enterobacteriaceae via ecological control

M Furuichi, T Kawaguchi, MM Pust, K Yasuma-Mitobe… - Nature, 2024 - nature.com
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …

Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

H Hou, D Chen, K Zhang, W Zhang, T Liu, S Wang… - Cancer Letters, 2022 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. It involves the complex interactions between genetic …

Functional and genomic variation between human-derived isolates of Lachnospiraceae reveals inter-and intra-species diversity

MT Sorbara, ER Littmann, E Fontana, TU Moody… - Cell host & …, 2020 - cell.com
Bacteria belonging to the Lachnospiraceae family are abundant, obligate anaerobic
members of the microbiota in healthy humans. Lachnospiraceae impact their hosts by …

Salmonella versus the Microbiome

AWL Rogers, RM Tsolis… - … and Molecular Biology …, 2021 - Am Soc Microbiol
SUMMARY A balanced gut microbiota contributes to health, but the mechanisms
maintaining homeostasis remain elusive. Microbiota assembly during infancy is governed by …