Epigenetics in obesity and diabetes mellitus: new insights

R Suárez, SP Chapela, L Álvarez-Córdova… - Nutrients, 2023 - mdpi.com
A long-term complication of obesity is the development of type 2 diabetes (T2D). Patients
with T2D have been described as having epigenetic modifications. Epigenetics is the post …

The metabolic syndrome, a human disease

M Alemany - International journal of molecular sciences, 2024 - mdpi.com
This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Association of visceral adiposity index with sarcopenia based on NHANES data

J Li, Y Lin, H Deng, X Su, W Feng, Q Shao, K Zou - Scientific Reports, 2024 - nature.com
Abstract The Visceral Adiposity Index (VAI) assesses visceral fat and related metabolic risks.
However, its precise correlation with sarcopenia is unclear. This study aimed to examine this …

Fatty acids and epigenetics in health and diseases

MY Chung, BH Kim - Food Science and Biotechnology, 2024 - Springer
Lipids are crucial for human health and reproduction and include diverse fatty acids (FAs),
notably polyunsaturated FAs (PUFAs) and short-chain FAs (SCFAs) that are known for their …

[HTML][HTML] TET3 plays a critical role in white adipose development and diet-induced remodeling

BC Jung, D You, I Lee, D Li, RL Schill, K Ma, A Pi… - Cell reports, 2023 - cell.com
Maintaining healthy adipose tissue is crucial for metabolic health, requiring a deeper
understanding of adipocyte development and response to high-calorie diets. This study …

A Predictive Tool Based on DNA Methylation Data for Personalized Weight Loss through Different Dietary Strategies: A Pilot Study

NC García-Álvarez, JI Riezu-Boj, JA Martínez… - Nutrients, 2023 - mdpi.com
Background and aims: Obesity is a public health problem. The usual treatment is a reduction
in calorie intake and an increase in energy expenditure, but not all individuals respond …

Palmitate-triggered cox2/pge2-related hyperinflammation in dual-stressed pdl fibroblasts is mediated by repressive h3k27 trimethylation

L Schuldt, M Reimann, K von Brandenstein… - Cells, 2022 - mdpi.com
The interrelationships between periodontal disease, obesity-related hyperlipidemia and
mechanical forces and their modulating effects on the epigenetic profile of periodontal …

LDL promotes disorders in β-cell cholesterol metabolism, implications on insulin cellular communication mediated by EVs

L Guevara-Olaya, B Chimal-Vega… - Metabolites, 2022 - mdpi.com
Dyslipidemia is described as a hallmark of metabolic syndrome, promoting a stage of
metabolic inflammation (metainflammation) that could lead to misbalances in energetic …

TNF-α/Stearate Induced H3K9/18 Histone Acetylation Amplifies IL-6 Expression in 3T3-L1 Mouse Adipocytes

F Bahman, A Al-Roub, N Akhter, A Al Madhoun… - International Journal of …, 2024 - mdpi.com
Extensive evidence supports the connection between obesity-induced inflammation and the
heightened expression of IL-6 adipose tissues. However, the mechanism underlying the IL-6 …

[HTML][HTML] Big data analytics in RNA-sequencing

WOO Sung-Hun, BC JUNG - Korean Journal of Clinical Laboratory Science, 2023 - kjcls.org
As next-generation sequencing has been developed and used widely, RNA-sequencing
(RNA-seq) has rapidly emerged as the first choice of tools to validate global transcriptome …