The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart
Cellular senescence is a condition characterized by stable, irreversible cell cycle arrest
linked to the aging process. The accumulation of senescent cells in the cardiac muscle can …
linked to the aging process. The accumulation of senescent cells in the cardiac muscle can …
Sex-Specific Response of the Brain Free Oxylipin Profile to Soluble Epoxide Hydrolase Inhibition
Oxylipins are the oxidation products of polyunsaturated fatty acids and have been implicated
in neurodegenerative disorders, including dementia. Soluble epoxide hydrolase (sEH) …
in neurodegenerative disorders, including dementia. Soluble epoxide hydrolase (sEH) …
Overcoming the Challenges of Multi‐Target‐Directed Ligands for Alzheimer's Disease: Tips and Examples
E Uliassi, AM Pasieka, E Diamanti… - … : Strategies for Multi …, 2025 - Wiley Online Library
The concept of multi‐target‐directed ligands has been quite successful within the drug
discovery community, due to its potential to better address the multifactorial nature of …
discovery community, due to its potential to better address the multifactorial nature of …
The effect of soluble epoxide hydrolase inhibition on the mononuclear phagocyte system during inflammation
OV Bracken - 2023 - discovery.ucl.ac.uk
Evidence suggests a role for Cytochrome P450 metabolites, namely the epoxy-oxylipins, in
facilitating the inflammatory response. The soluble epoxide hydrolase (sEH) enzyme …
facilitating the inflammatory response. The soluble epoxide hydrolase (sEH) enzyme …
[HTML][HTML] Ureas derived from camphor and fenchone reveal enantiomeric preference of human soluble epoxide hydrolase
V Burmistrov, C Morisseau, D Pitushkin, RR Fayzullin… - Results in chemistry, 2022 - Elsevier
The soluble epoxide hydrolase (sEH) is a potential target to treat cardiovascular, renal and
neuronal diseases. A series of sEH inhibitors containing naturally occurring lipophilic groups …
neuronal diseases. A series of sEH inhibitors containing naturally occurring lipophilic groups …
Ureas derived from camphor and fenchone reveal enantiomeric preference of human soluble epoxide hydrolase
V Burmistrov, C Morisseau, D Pitushkin, RR Fayzullin… - 2022 - escholarship.org
The soluble epoxide hydrolase (sEH) is a potential target to treat cardiovascular, renal and
neuronal diseases. A series of sEH inhibitors containing naturally occurring lipophilic groups …
neuronal diseases. A series of sEH inhibitors containing naturally occurring lipophilic groups …