The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …

Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having
plethora of applications in anticancer drug development. These synthetic sources serve as …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a
promising target for the treatment of cancer; however, the MCT1 modulator landscape is …

Multitarget datasets that correlate bioactivity landscapes of small-molecules toward different
related or unrelated pharmacological targets are crucial for novel drug design and …

ABCB1 and ABCG2 are the important ATP-binding cassette (ABC) transporters associated
with multidrug resistance (MDR). Herein, we designed a series of imidazo [1, 2-a] pyridine …

Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to
overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to …

Simple Summary Reusing drugs could potentially shorten the development time for the
effective treatment of dementia. Here, we tested a drug—dimethyl fumarate—for its efficacy …

Based on literature reports of the last two decades, a computer-aided pattern analysis (C@
PA) was implemented for the discovery of novel multitarget ABCB1 (P-gp), ABCC1 (MRP1) …

Abstract Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are
ubiquitously present membrane-bound efflux pumps that distribute endo-and xenobiotics …