Phosphatases are important regulators of intracellular signaling events, and their functions
have been implicated in many biological processes. Dual-specificity phosphatases …

Inflammatory arthritis occurs in many diseases and is characterized by joint inflammation
and damage. However, the inflammatory state in arthritis is commonly associated with …

Liver fibrosis is a severe, life-threatening clinical condition resulting from nonresolving
hepatitis of different origins. IL-17A is critical in inflammation, but its relation to liver fibrosis …

Vascular oxidative injury accompanies many common conditions associated with
hypertension. In the present study, we employed mouse models with excessive vascular …

Disruption of the balance among the microbiota, epithelial cells, and resident immune cells
in the intestine is involved in the pathogenesis of inflammatory bowel disease (IBD) …

Adaptive immune response has been implicated in inflammation and fibrosis as a result of
exposure to mineralocorticoids and a high-salt diet. We hypothesized that in …

It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …

The cardiac fibroblast is a remarkably versatile cell type that coordinates inflammatory,
fibrotic and hypertrophic responses in the heart through a complex array of intracellular and …

The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel
that plays a critical role in the lung by maintaining fluid homeostasis. Absence or malfunction …

Cardiac fibroblasts (CF) play a pivotal role in the repair and remodeling of the heart that
occur following myocardial infarction (MI). The transition through the inflammatory …