Principles of alternating access in LeuT-fold transporters: commonalities and divergences
Found in all domains of life, transporters belonging to the LeuT-fold class mediate the import
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …
[HTML][HTML] Functional crosstalk of the glycine transporter GlyT1 and NMDA receptors
D Piniella, F Zafra - Neuropharmacology, 2023 - Elsevier
NMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu)
targets in the central nervous system and are involved in synaptic plasticity, which is the …
targets in the central nervous system and are involved in synaptic plasticity, which is the …
Conformational dynamics of the human serotonin transporter during substrate and drug binding
IR Möller, M Slivacka, AK Nielsen… - Nature …, 2019 - nature.com
The serotonin transporter (SERT), a member of the neurotransmitter: sodium symporter
family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5 …
family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5 …
Substrate-induced conformational dynamics of the dopamine transporter
AK Nielsen, IR Möller, SGF Rasmussen, KD Rand… - Biophysical …, 2019 - cell.com
The dopamine transporter is a member of the neurotransmitter: sodium symporters (NSSs),
which are responsible for termination of neurotransmission through Na+-driven reuptake of …
which are responsible for termination of neurotransmission through Na+-driven reuptake of …
Allosteric mechanisms of molecular machines at the membrane: transport by sodium-coupled symporters
Solute transport across cell membranes is ubiquitous in biology as an essential
physiological process. Secondary active transporters couple the unfavorable process of …
physiological process. Secondary active transporters couple the unfavorable process of …
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Neurotransmitter: sodium symporters (NSS) are conserved from bacteria to man and serve
as targets for drugs, including antidepressants and psychostimulants. Here we report the X …
as targets for drugs, including antidepressants and psychostimulants. Here we report the X …
Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT
LeuT, a prokaryotic member of the neurotransmitter: sodium symporter (NSS) family, is an
established structural model for mammalian NSS counterparts. We investigate the substrate …
established structural model for mammalian NSS counterparts. We investigate the substrate …
Highly branched pentasaccharide-bearing amphiphiles for membrane protein studies
Detergents are essential tools for membrane protein manipulation. Micelles formed by
detergent molecules have the ability to encapsulate the hydrophobic domains of membrane …
detergent molecules have the ability to encapsulate the hydrophobic domains of membrane …
Technologies, strategies, and cautions when deconvoluting genome‐wide association signals: FTO in focus
Genome‐wide association studies have revealed a plethora of genetic variants that
correlate with polygenic conditions. However, causal molecular mechanisms have proven …
correlate with polygenic conditions. However, causal molecular mechanisms have proven …
A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
Abstract Neurotransmitter: sodium symporters (NSS), targets of antidepressants and
psychostimulants, clear neurotransmitters from the synaptic cleft through sodium (Na+) …
psychostimulants, clear neurotransmitters from the synaptic cleft through sodium (Na+) …