Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest
malignant types of primary astrocytoma with a poor prognosis. At present, the standard of …

Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …

A unique robotic medical platform is designed by utilizing cell robots as the active “Trojan
horse” of oncolytic adenovirus (OA), capable of tumor‐selective binding and killing. The OA …

Brain tumors are a diverse group of neoplasms that often carry a poor prognosis for patients.
Despite tremendous efforts to develop diagnostic tools and therapeutic avenues, the …

Background: Glioblastoma multiforme (GBM) is the most common and lethal primary
malignancy of the central nervous system (CNS). Despite the proven benefit of surgical …

Metastatic cancer cells generally cannot be eradicated using traditional surgical or
chemoradiotherapeutic strategies, and disease recurrence is extremely common following …

Cell-based therapy is a promising modality to address many unmet medical needs. In
addition to genetic engineering, material-based, biochemical, and physical science-based …

Viruses as cancer therapies have attracted attention since the 19th century. Scientists
observation that viruses can preferentially lyse cancer cells rather than healthy cells, created …

High-grade gliomas are extremely difficult to treat because they are invasive and therefore
not curable by surgical resection; the toxicity of current chemo-and radiation therapies limits …

Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to
selectively infect, replicate in, and lyse malignant cells without causing harm to normal …