Cancer continues to be a leading threat to human health and life. Resistance to anti-cancer
drugs is a major impediment towards efficacious cancer treatment. p53 mutations play an …

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and
human health. Impaired apoptosis is associated with a variety of human diseases, including …

To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-
Cas9 knockout (KO) screens in patient-derived GBM stem-like cells (GSCs) and human …

The p53 tumor suppressor protein is involved in regulating a wide variety of stress
responses, from senescence and apoptosis to more recently discovered roles in allowing …

The tumor suppressor p53 plays various functional roles in the cell by regulating multiple
regulatory signals that ensure adequate temporal and spatial responses to cellular stress …

There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct
classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have …

Background: p53 plays an important role in many areas of cellular physiology and biology,
ranging from cellular development and differentiation to cell cycle arrest and apoptosis …

The interaction of legumes with N2-fixing bacteria collectively called rhizobia results in root
nodule development. The number of nodules formed is tightly restricted through the systemic …

Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing
family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is …

The constitutive photomorphogenesis 9 signalosome (COP9 or CSN) is an evolutionarily
conserved multiprotein complex found in plants and animals. Because of the homology …