Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

Histologic transformation (HT) to an aggressive lymphoma is a well-described event in the
natural history and clinical course of patients with so-called indolent lymphomas. This …

Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL)
derive from germinal center B cells. Targeted resequencing studies have revealed mutations …

EZH2, the catalytic subunit of the PRC2 complex, catalyzes the mono-through trimethylation
of lysine 27 on histone H3 (H3K27). Histone H3K27 trimethylation is a mechanism for …

We analyzed the DNA methylome of ten subpopulations spanning the entire B cell
differentiation program by whole-genome bisulfite sequencing and high-density microarrays …

In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …

EZH2 is the catalytic subunit of the PRC2 Polycomb complex and mediates transcriptional
repression through its histone methyltransferase activity. EZH2 is up-regulated in normal …

The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be
reversed have favoured development of epigenetic drugs. In this study, we design and …

Introduction Five different molecular subtypes of breast cancer have been identified through
gene expression profiling. Each subtype has a characteristic expression pattern suggested …

Heterozygous point mutations at Y641 and A677 in the EZH2 SET domain are prevalent in
about 10–24% of Non-Hodgkin lymphomas (NHL). Previous studies indicate that these are …