Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Abstract Carboxylesterases (CES1 and CES2) and arylacetamide deacetylase (AADAC),
which are expressed primarily in the liver and/or gastrointestinal tract, hydrolyze drugs …

The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by
intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …

ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …

Human carboxylesterases (CESs) are serine hydrolases that are responsible for the phase I
metabolism of an assortment of ester, amide, thioester, carbonate, and carbamate …

Cardiovascular diseases (CVDs) have a high mortality rate, and despite the several
available therapeutic targets, non-response to antihypertensives remains a common …

Literature data and authors' own results on the role of serine hydrolases,
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), as drug targets for treatment …

Human liver microsomes (HLM) and human liver S9 fractions (HLS9) are commonly used to
study drug metabolism in vitro. However, a quantitative comparison of HLM and HLS9 …

Sacubitril was recently approved by the Food and Drug Administration for use in
combination with valsartan for the treatment of patients with heart failure with reduced …