Lung endothelium, tau, and amyloids in health and disease
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …
Oh my gut! Is the microbial origin of neurodegenerative diseases real?
There is no cure or effective treatment for neurodegenerative protein conformational
diseases (PCDs), such as Alzheimer's or Parkinson's diseases, mainly because the etiology …
diseases (PCDs), such as Alzheimer's or Parkinson's diseases, mainly because the etiology …
Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice
Compelling evidence supports vascular contributions to cognitive impairment and dementia
(VCID) including Alzheimer's disease (AD), but the underlying pathogenic mechanisms and …
(VCID) including Alzheimer's disease (AD), but the underlying pathogenic mechanisms and …
The anesthetic sevoflurane induces tau trafficking from neurons to microglia
Accumulation and spread of tau in Alzheimer's disease and other tauopathies occur in a
prion-like manner. However, the mechanisms and downstream consequences of tau …
prion-like manner. However, the mechanisms and downstream consequences of tau …
New insights into clinical and mechanistic heterogeneity of the acute respiratory distress syndrome: summary of the Aspen Lung Conference 2021
TR Martin, RL Zemans, LB Ware… - American journal of …, 2022 - atsjournals.org
Clinical and molecular heterogeneity are common features of human disease.
Understanding the basis for heterogeneity has led to major advances in therapy for many …
Understanding the basis for heterogeneity has led to major advances in therapy for many …
Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy
Patients who recover from nosocomial pneumonia oftentimes exhibit long-lasting cognitive
impairment comparable with what is observed in Alzheimer's disease patients. We …
impairment comparable with what is observed in Alzheimer's disease patients. We …
Pneumonia initiates a tauopathy
R Balczon, MT Lin, JY Lee, A Abbasi… - The FASEB …, 2021 - Wiley Online Library
Pneumonia causes short‐and long‐term cognitive dysfunction in a high proportion of
patients, although the mechanism (s) responsible for this effect are unknown. Here, we …
patients, although the mechanism (s) responsible for this effect are unknown. Here, we …
[HTML][HTML] Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions
Pseudomonas aeruginosa infection elicits the production of cytotoxic amyloids from lung
endothelium, yet molecular mechanisms of host‐pathogen interaction that underlie the …
endothelium, yet molecular mechanisms of host‐pathogen interaction that underlie the …
Neurovascular Dysfunction in Diverse Communities With Health Disparities—Contributions to Dementia and Alzheimer's Disease
N Saiyasit, EAR Butlig, SD Chaney… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease and related dementias (ADRD) are an expanding worldwide crisis. In
the absence of scientific breakthroughs, the global prevalence of ADRD will continue to …
the absence of scientific breakthroughs, the global prevalence of ADRD will continue to …
Perspectives on the Pseudomonas aeruginosa Type III Secretion System Effector ExoU and Its Subversion of the Host Innate Immune Response to Infection
KS Hardy, MH Tessmer, DW Frank, JP Audia - Toxins, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic, Gram-negative pathogen and an important
cause of hospital acquired infections, especially in immunocompromised patients. Highly …
cause of hospital acquired infections, especially in immunocompromised patients. Highly …