Research on newborn immunity has revealed the importance of cell ontogeny, feto-maternal
tolerance, and the transfer of maternal antibodies. Less is known about postnatal adaptation …

Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain
organismal homeostasis. Circadian and stress-induced changes in systemic GC levels …

Mental health profoundly impacts inflammatory responses in the body. This is particularly
apparent in inflammatory bowel disease (IBD), in which psychological stress is associated …

Race-based medicine has been pervasively interwoven into the fabric of health care
delivery in the United States for more than 400 years. Race is a historically derived social …

Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …

Stress is an essential adaptive response that enables the organism to cope with challenges
and restore homeostasis. Different stressors require distinctive corrective responses in …

The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue
stress, damage or infection has a decisive role in determining immune responses. Since …

Among all major organs, the brain is one of the most susceptible to the inexorable effects of
aging. Throughout the last decades, several studies in human cohorts and animal models …

A poor socioeconomic environment and social adversity are fundamental determinants of
human life span, well-being and health. Previous influenza pandemics showed that …

Glucocorticoids (GCs) are a class of steroid hormones secreted from the adrenal cortex.
Their production is controlled by circadian rhythm and stress, the latter of which includes …