Iron is one of the crucial elements required for the growth of Mycobacterium tuberculosis.
However, excess free iron becomes toxic for the cells because it catalyzes the production of …

The importance of inter-and intracellular signal transduction in all forms of life cannot be
underestimated. A large number of genes dedicated to cellular signalling are found in …

DevR regulon function is believed to be crucial for the survival of Mycobacterium
tuberculosis during dormancy. In this study, we undertook a comprehensive analysis of the …

Background The DevR (DosR) regulon is implicated in hypoxic adaptation and virulence of
Mycobacterium tuberculosis. The present study was designed to decipher the impact of …

Tuberculosis is recognized as one of the major public health threats worldwide. The DevR–
DevS (DosR/DosS) two-component system is considered a novel drug target in …

The DevR response regulator of Mycobacterium tuberculosis is an established regulator of
the dormancy response in mycobacteria and can also be activated during aerobic growth …

Background Two-component systems have emerged as compelling targets for antibacterial
drug design for a number of reasons including the distinct histidine phosphorylation property …

DevR is a key regulator of the dormancy response in Mycobacterium tuberculosis (M. tb).
Using DevR as bait to screen a phage display library, a peptide, DevRS1, was obtained …

Summary The DevRS/DosT two‐component system is essential for mycobacterial survival
under hypoxia, a prevailing stress within granulomas. DevR (also known as DosR) is …

DevR/DosR is a key mediator of 'dormancy'adaptation in Mycobacterium tuberculosis in
response to gaseous stresses such as hypoxia that inhibit aerobic mode of respiration. In the …