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New therapeutic approaches to Parkinson's disease targeting GBA, LRRK2 and Parkin
Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …
Risk of dementia in Parkinson's disease: a systematic review and meta‐analysis
LL Gibson, D Weintraub, R Lemmen… - Movement …, 2024 - Wiley Online Library
Estimates of the risk of dementia in Parkinson's disease (PDD) vary widely. We aimed to
review the incidence of PDD and in a meta‐analysis estimate the pooled annual incidence …
review the incidence of PDD and in a meta‐analysis estimate the pooled annual incidence …
Large-scale rare variant burden testing in Parkinson's disease
Parkinson's disease has a large heritable component and genome-wide association studies
have identified over 90 variants with disease-associated common variants, providing deeper …
have identified over 90 variants with disease-associated common variants, providing deeper …
A randomized placebo-controlled study of a transcranial photobiomodulation helmet in Parkinson's disease: post-hoc analysis of motor outcomes
Emerging evidence is increasingly supporting the use of transcranial photobiomodulation
(tPBM) to improve symptoms of neurodegenerative diseases, including Parkinson's disease …
(tPBM) to improve symptoms of neurodegenerative diseases, including Parkinson's disease …
[HTML][HTML] Clinical phenotypes of Parkinson's disease associate with distinct gut microbiota and metabolome enterotypes
S Vascellari, M Melis, V Palmas, S Pisanu, A Serra… - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) is a clinically heterogenic disorder characterized by distinct clinical
entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non …
entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non …
Access to device-aided therapies in advanced Parkinson's disease: navigating clinician biases, patient preference, and prognostic uncertainty
Abstract Device-aided therapies (DAT), which include deep brain stimulation and pump-
based continuous dopaminergic stimulation with either levodopa or apomorphine, are …
based continuous dopaminergic stimulation with either levodopa or apomorphine, are …
Non-invasive electrical stimulation of peripheral nerves for the management of tremor
Pathological tremor in patients with essential tremor and Parkinsons disease is typically
treated using medication or neurosurgical interventions. There is a widely recognized need …
treated using medication or neurosurgical interventions. There is a widely recognized need …
[HTML][HTML] Apathy in Parkinson's disease: defining the park apathy subtype
Apathy is a neurobehavioural symptom affecting Parkinson's disease patients of all disease
stages. Apathy seems to be associated with a specific underlying non-motor disease …
stages. Apathy seems to be associated with a specific underlying non-motor disease …
Chaudhuri's Dashboard of Vitals in Parkinson's syndrome: an unmet need underpinned by real life clinical tests
We have recently published the notion of the “vitals” of Parkinson's, a conglomeration of
signs and symptoms, largely nonmotor, that must not be missed and yet often not considered …
signs and symptoms, largely nonmotor, that must not be missed and yet often not considered …
Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review
I Parrotta, S Cacciatore, F D'Andrea, M D'Anna… - Neurological …, 2024 - Springer
Objectives The aim of this review is to provide an overview on prevalence and clinical tools
for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings …
for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings …