New therapeutic approaches to Parkinson's disease targeting GBA, LRRK2 and Parkin

K Senkevich, U Rudakou, Z Gan-Or - Neuropharmacology, 2022 - Elsevier
Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis,
yet a more accurate definition could be that PD is not a single entity, but rather a mixture of …

Risk of dementia in Parkinson's disease: a systematic review and meta‐analysis

LL Gibson, D Weintraub, R Lemmen… - Movement …, 2024 - Wiley Online Library
Estimates of the risk of dementia in Parkinson's disease (PDD) vary widely. We aimed to
review the incidence of PDD and in a meta‐analysis estimate the pooled annual incidence …

Large-scale rare variant burden testing in Parkinson's disease

MB Makarious, J Lake, V Pitz, A Ye Fu, JL Guidubaldi… - Brain, 2023 - academic.oup.com
Parkinson's disease has a large heritable component and genome-wide association studies
have identified over 90 variants with disease-associated common variants, providing deeper …

A randomized placebo-controlled study of a transcranial photobiomodulation helmet in Parkinson's disease: post-hoc analysis of motor outcomes

C McGee, A Liebert, B Bicknell, V Pang, V Isaac… - Journal of Clinical …, 2023 - mdpi.com
Emerging evidence is increasingly supporting the use of transcranial photobiomodulation
(tPBM) to improve symptoms of neurodegenerative diseases, including Parkinson's disease …

[HTML][HTML] Clinical phenotypes of Parkinson's disease associate with distinct gut microbiota and metabolome enterotypes

S Vascellari, M Melis, V Palmas, S Pisanu, A Serra… - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) is a clinically heterogenic disorder characterized by distinct clinical
entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non …

Non-invasive electrical stimulation of peripheral nerves for the management of tremor

A Pascual-Valdunciel, A Rajagopal, JL Pons… - Journal of the …, 2022 - Elsevier
Pathological tremor in patients with essential tremor and Parkinsons disease is typically
treated using medication or neurosurgical interventions. There is a widely recognized need …

[HTML][HTML] Apathy in Parkinson's disease: defining the park apathy subtype

S De Waele, P Cras, D Crosiers - Brain Sciences, 2022 - mdpi.com
Apathy is a neurobehavioural symptom affecting Parkinson's disease patients of all disease
stages. Apathy seems to be associated with a specific underlying non-motor disease …

Chaudhuri's Dashboard of Vitals in Parkinson's syndrome: an unmet need underpinned by real life clinical tests

MA Qamar, S Rota, L Batzu, I Subramanian… - Frontiers in …, 2023 - frontiersin.org
We have recently published the notion of the “vitals” of Parkinson's, a conglomeration of
signs and symptoms, largely nonmotor, that must not be missed and yet often not considered …

Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

I Parrotta, S Cacciatore, F D'Andrea, M D'Anna… - Neurological …, 2024 - Springer
Objectives The aim of this review is to provide an overview on prevalence and clinical tools
for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings …