Autoimmune hepatitis (AIH) is an inflammatory liver disease, affecting mainly females,
characterized by elevated transaminase and immunoglobulin G (IgG) levels, interface …

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …

Primary immunodeficiencies (PIDs), a heterogenous group of inborn errors of immunity, are
predetermined at birth but may evolve with age, leading to a variable clinical and laboratory …

The profound impact that vision loss has on human activities and quality of life necessitates
understanding the etiology of potentially blinding diseases and their clinical management …

Pulmonary hypertension (PH) is a malignant disease with progressive increase of
pulmonary vascular pressure, which eventually leads to right heart failure. More and more …

Background: Key characteristics (KCs), properties of agents or exposures that confer
potential hazard, have been developed for carcinogens and other toxicant classes. KCs …

Autoimmune diseases are a group of serious immune system disorders that are usually
idiopathic and persistent. Currently, autoimmune diseases are often diagnosed after obvious …

Abstract Phosphatidylinositol 3 kinases (PI3K) are a family of lipid kinases that are activated
by a variety of cell‐surface receptors, and regulate a wide range of downstream readouts …

Nuclease-based genome editing strategies hold great promise for the treatment of blood
disorders. However, a major drawback of these approaches is the generation of potentially …

During the last years, studies investigating the intriguing association between
immunodeficiency and autoimmunity led to the discovery of new monogenic disorders, the …