Raman spectroscopy: an emerging tool in neurodegenerative disease research and diagnosis
G Devitt, K Howard, A Mudher… - ACS chemical …, 2018 - ACS Publications
The pathogenesis underlining many neurodegenerative diseases remains incompletely
understood. The lack of effective biomarkers and disease preventative medicine demands …
understood. The lack of effective biomarkers and disease preventative medicine demands …
Exploring the structure and formation mechanism of amyloid fibrils by Raman spectroscopy: a review
Amyloid fibrils are β-sheet rich protein aggregates that are strongly associated with various
neurodegenerative diseases. Raman spectroscopy has been broadly utilized to investigate …
neurodegenerative diseases. Raman spectroscopy has been broadly utilized to investigate …
Raman spectroscopy on brain disorders: transition from fundamental research to clinical applications
Brain disorders such as brain tumors and neurodegenerative diseases (NDs) are
accompanied by chemical alterations in the tissues. Early diagnosis of these diseases will …
accompanied by chemical alterations in the tissues. Early diagnosis of these diseases will …
Structural basis of huntingtin fibril polymorphism revealed by cryogenic electron microscopy of exon 1 HTT fibrils
The lack of detailed insight into the structure of aggregates formed by the huntingtin protein
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …
Live-cell imaging and quantification of PolyQ aggregates by stimulated Raman scattering of selective deuterium labeling
Polyglutamine (polyQ) diseases are a group of neurodegenerative disorders, involving the
deposition of aggregation-prone proteins with long polyQ expansions. However, the …
deposition of aggregation-prone proteins with long polyQ expansions. However, the …
Structural motif of polyglutamine amyloid fibrils discerned with mixed-isotope infrared spectroscopy
Polyglutamine (polyQ) sequences are found in a variety of proteins, and mutational
expansion of the polyQ tract is associated with many neurodegenerative diseases. We study …
expansion of the polyQ tract is associated with many neurodegenerative diseases. We study …
Ultraviolet resonance Raman spectroscopic markers for protein structure and dynamics
UV resonance Raman (UVRR) spectroscopy is a powerful tool for investigating the structure
of biological molecules, such as proteins. Numerous UVRR spectroscopic markers that …
of biological molecules, such as proteins. Numerous UVRR spectroscopic markers that …
Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington's disease
Huntington's disease, like other neurodegenerative diseases, continues to lack an effective
cure. Current treatments that address early symptoms ultimately fail Huntington's disease …
cure. Current treatments that address early symptoms ultimately fail Huntington's disease …
Engaging with Raman spectroscopy to investigate antibody aggregation
I Ettah, L Ashton - Antibodies, 2018 - mdpi.com
In the last decade, a number of studies have successfully demonstrated Raman
spectroscopy as an emerging analytical technique for monitoring antibody aggregation …
spectroscopy as an emerging analytical technique for monitoring antibody aggregation …
Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease
Neurodegeneration in Huntington's disease (HD) is accompanied by the aggregation of
fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular …
fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular …