The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the develo** neuron. Regulation of polymer …

The establishment of precise neuronal cell morphology provides the foundation for all
aspects of neurobiology. During development, axons emerge from cell bodies after an initial …

The molecular mechanisms underlying the axon arborization of mammalian neurons are
poorly understood but are critical for the establishment of functional neural circuits. We …

The remarkable ability of a single axon to extend multiple branches and form terminal arbors
enables vertebrate neurons to integrate information from divergent regions of the nervous …

Fibroblast growth factors (FGFs) and their receptors constitute an elaborate signaling system
that participates in many developmental and repair processes of virtually all mammalian …

Cortical neurons innervate many of their targets by collateral axon branching, which requires
local reorganization of the cytoskeleton. We coinjected cortical neurons with fluorescently …

Filopodia are thin cellular protrusions that are important in cell motility and neuronal growth
cone guidance. The actin filaments that make up the core of a filopodium undergo …

Dendritic spines are the primary sites of contact with presynaptic axons on excitatory
hippocampal and cortical neurons. During development and plasticity spines undergo …

Ca2+ signals have profound and varied effects on growth cone motility and guidance.
Modulation of Ca2+ influx and release from stores by guidance cues shapes Ca2+ signals …