Brain atrophy in Alzheimer's disease and aging

L Pini, M Pievani, M Bocchetta, D Altomare… - Ageing research …, 2016‏ - Elsevier
Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

Inflammatory aspects of Alzheimer's disease

P Botella Lucena, MT Heneka - Acta Neuropathologica, 2024‏ - Springer
Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease

C Depp, T Sun, AO Sasmita, L Spieth, SA Berghoff… - Nature, 2023‏ - nature.com
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease

MI Gabitto, KJ Travaglini, VM Rachleff, ES Kaplan… - Nature …, 2024‏ - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Inflammatory process in Alzheimer's Disease

MA Meraz-Ríos, D Toral-Rios… - Frontiers in integrative …, 2013‏ - frontiersin.org
Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Histopathologically is characterized by the presence of two major hallmarks, the …

Myelin lipid metabolism and its role in myelination and myelin maintenance

JA Barnes-Vélez, FBA Yasar, J Hu - The Innovation, 2023‏ - cell.com
Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

M Pievani, N Filippini, MP Van Den Heuvel… - Nature Reviews …, 2014‏ - nature.com
Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …

Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors

M Schumacher, C Mattern, A Ghoumari… - Progress in …, 2014‏ - Elsevier
Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

RJ Bateman, PS Aisen, B De Strooper, NC Fox… - Alzheimer's research & …, 2011‏ - Springer
Autosomal-dominant Alzheimer's disease has provided significant understanding of the
pathophysiology of Alzheimer's disease. The present review summarizes clinical …

Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric map**: application to normal elderly and Alzheimer's disease …

K Oishi, A Faria, H Jiang, X Li, K Akhter, J Zhang… - Neuroimage, 2009‏ - Elsevier
The purpose of this paper is to establish single-participant white matter atlases based on
diffusion tensor imaging. As one of the applications of the atlas, automated brain …