Approaches for bacteriophage genome engineering
In recent years, bacteriophage research has been boosted by a rising interest in using
phage therapy to treat antibiotic-resistant bacterial infections. In addition, there is a desire to …
phage therapy to treat antibiotic-resistant bacterial infections. In addition, there is a desire to …
Genetic engineering of bacteriophages: Key concepts, strategies, and applications
Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …
amount of unexplored genetic information. Since their discovery, phages have drawn a great …
Bacteriophage and endolysin engineering for biocontrol of food pathogens/pathogens in the food: recent advances and future trends
C Lee, H Kim, S Ryu - CritiCal reviews in Food sCienCe and …, 2023 - Taylor & Francis
Despite advances in modern technologies, various foodborne outbreaks have continuously
threatened the food safety. The overuse of and abuse/misuse of antibiotics have escalated …
threatened the food safety. The overuse of and abuse/misuse of antibiotics have escalated …
Engineering Phages to Fight Multidrug-Resistant Bacteria
Facing the global “superbug” crisis due to the emergence and selection for antibiotic
resistance, phages are among the most promising solutions. Fighting multidrug-resistant …
resistance, phages are among the most promising solutions. Fighting multidrug-resistant …
T4 phage display technology for enhanced photodynamic therapy of breast cancer
XL Hou, XT **e, LF Tan, F Zhang, JX Fan… - ACS Materials …, 2023 - ACS Publications
Hypoxia in tumor tissues is the major obstacle to photodynamic therapy (PDT). Herein, a self-
oxygenating nanoplatform T4-Ce6-Cat (T4CCa) is used for improving PDT. T4 acts as a …
oxygenating nanoplatform T4-Ce6-Cat (T4CCa) is used for improving PDT. T4 acts as a …
Engineering bacteriophages for enhanced host range and efficacy: Insights from bacteriophage-bacteria interactions
HJ Jia, PP Jia, S Yin, LK Bu, G Yang… - Frontiers in Microbiology, 2023 - frontiersin.org
Bacteriophages, the most abundant organisms on earth, have the potential to address the
rise of multidrug-resistant bacteria resulting from the overuse of antibiotics. However, their …
rise of multidrug-resistant bacteria resulting from the overuse of antibiotics. However, their …
Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications
Lytic bacteriophages hold substantial promise in medical and biotechnological applications.
Therefore a comprehensive understanding of phage infection mechanisms is crucial …
Therefore a comprehensive understanding of phage infection mechanisms is crucial …
T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines
M Li, C Chen, X Wang, P Guo, H Feng, X Zhang… - Antiviral Research, 2023 - Elsevier
Vaccines that trigger mucosal immune responses at the entry portals of pathogens are
highly desired. Here, we showed that antigen-decorated nanoparticle generated through …
highly desired. Here, we showed that antigen-decorated nanoparticle generated through …
Monomeric streptavidin phage display allows efficient immobilization of bacteriophages on magnetic particles for the capture, separation, and detection of bacteria
Immobilization of bacteriophages onto solid supports such as magnetic particles has
demonstrated ultralow detection limits as biosensors for the separation and detection of their …
demonstrated ultralow detection limits as biosensors for the separation and detection of their …
Landscape of new nuclease-containing antiphage systems in Escherichia coli and the counterdefense roles of bacteriophage T4 genome modifications
S Wang, E Sun, Y Liu, B Yin, X Zhang, M Li… - Journal of …, 2023 - Am Soc Microbiol
Many phages, such as T4, protect their genomes against the nucleases of bacterial
restriction-modification (RM) and CRISPR-Cas systems through covalent modification of …
restriction-modification (RM) and CRISPR-Cas systems through covalent modification of …