Scanning probe microscopy
Scanning probe microscopy (SPM), a key invention in nanoscience, has by now been
extended to a wide spectrum of basic and applied fields. Its application to basic science led …
extended to a wide spectrum of basic and applied fields. Its application to basic science led …
Challenges and opportunities in cryo-EM single-particle analysis
D Lyumkis - Journal of Biological Chemistry, 2019 - ASBMB
Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …
macromolecular objects and their assemblies. Although the techniques have been …
New tools for automated cryo-EM single-particle analysis in RELION-4.0
We describe new tools for the processing of electron cryo-microscopy (cryo-EM) images in
the fourth major release of the RELION software. In particular, we introduce VDAM, a …
the fourth major release of the RELION software. In particular, we introduce VDAM, a …
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no
specific and effective drugs for treating this disease have been reported until today …
specific and effective drugs for treating this disease have been reported until today …
CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks
Cryo-electron microscopy (cryo-EM) single-particle analysis has proven powerful in
determining the structures of rigid macromolecules. However, many imaged protein …
determining the structures of rigid macromolecules. However, many imaged protein …
Nuclear pores dilate and constrict in cellulo
INTRODUCTION The nucleus harbors and protects the genetic information in eukaryotes. It
is surrounded by the nuclear envelope, which separates the nucleoplasm from the cytosol …
is surrounded by the nuclear envelope, which separates the nucleoplasm from the cytosol …
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro
Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
COVID19 pandemic, is a highly pathogenic β-coronavirus. As other coronaviruses, SARS …
COVID19 pandemic, is a highly pathogenic β-coronavirus. As other coronaviruses, SARS …
Cryo-EM structures of SARS-CoV-2 spike without and with ACE2 reveal a pH-dependent switch to mediate endosomal positioning of receptor-binding domains
The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH …
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43
Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative
condition after Alzheimer's and Parkinson's diseases. FTLD typically presents in 45 to 64 …
condition after Alzheimer's and Parkinson's diseases. FTLD typically presents in 45 to 64 …