Contemporary sequencing studies often ignore the diploid nature of the human genome
because they do not routinely separate or'phase'maternally and paternally derived …

The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Since associations between complex diseases and common variants are typically weak, and
approaches to genoty** rare variants (eg by next-generation resequencing) multiply, there …

The secretory prohormone chromogranin A (CHGA) is overexpressed in essential
hypertension, a complex trait with genetic predisposition, while its catecholamine release …

Catestatin is a multifunctional peptide that is involved in the regulation of the cardiovascular
and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive …

Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …

Accounting for almost one-third of the global mortality, cardiovascular diseases (CVDs)
represent a major global health issue. Emerging data suggest that most of the well …

Circulating levels of catestatin (Cts; human chromogranin A352–372) decrease in the
plasma of patients with essential hypertension. Genetic ablation of the chromogranin A …

In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA] 344–
364: RSMRLSFRARGYGFRGPGLQL; human CHGA352–372 …

Hypertension is associated with inflammation and excessive production of catecholamines.
Hypertensive patients have reduced plasma levels of CST (catestatin)—a bioactive …