The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to
regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a …

Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of
members of the long-chain helical cytokine family. It is mainly produced by adipocytes in …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Various epidemiologic studies have shown that obesity is associated with hepatocellular
carcinoma. Leptin, the key player in the regulation of energy balance and body weight …

The discovery of leptin was a major breakthrough in our understanding of the role of adipose
tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent …

Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

Central control of energy balance depends on the ability of proopiomelanocortin (POMC) or
agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in …

Leptin, a protein hormone produced by the adipocytes, has long been recognized to
regulate metabolism, neuroendorine and other physiological functions. Early findings of …

Leptin, the protein product of the obese (ob or Lep) gene, is a hormone synthesized by
adipocytes that signals available energy reserves to the brain, and thereby influences …