As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high
mortality in industrialized countries: cardiovascular disease and diabetes. An important …

Mitochondrial damage causes mitochondrial DNA (mtDNA) release to activate the type I
interferon (IFN-I) response via the cGAS-STING pathway. mtDNA-induced inflammation …

Mitochondrial proteases are emerging as key regulators of mitochondrial plasticity and
acting as both protein quality surveillance and regulatory enzymes by performing highly …

Ischaemia of the heart and limbs attributable to compromised blood supply is a major cause
of mortality and morbidity. The mechanisms of functional angiogenesis remain poorly …

Sarcopenia, characterized by a loss of muscle mass and strength with aging, is prevalent in
older adults. Although the exact mechanisms underlying sarcopenia are not fully …

The mitochondrial protease Lonp1 is a multifunctional enzyme that regulates crucial
mitochondrial functions, including the degradation of oxidized proteins, folding of imported …