Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …

Checkpoint blockade mediates a proliferative response of tumor-infiltrating CD8+ T
lymphocytes (TILs). The origin of this response has remained elusive because chronic …

Chronic viral infections are characterized by a state of CD8+ T-cell dysfunction that is
associated with expression of the programmed cell death 1 (PD-1) inhibitory receptor,,,. A …

Platelet dysregulation is drastically increased with advanced age and contributes to making
cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a …

A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …

CAR T-cell product quality and stemness (Tstem) are major determinants of in vivo
expansion, efficacy, and clinical response. Prolonged ex vivo culturing is known to deplete …

Macrophages are one of the most diverse cell populations in terms of their anatomical
location and functional specialization during both homeostasis and disease. Although it has …

Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

Haematopoietic stem cells (HSCs) maintain balanced self-renewal and differentiation, but
how these functions are precisely regulated is not fully understood. N 6-methyladenosine …