Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Induced pluripotent stem cell (iPSC)-derived dopamine neurons provide an opportunity to
model Parkinson's disease (PD), but neuronal cultures are confounded by asynchronous …

Major depressive disorder is one of the most common mental illnesses as it affects more
than 350 million people globally. Major depressive disorder is etiologically complex and …

The acetylation and deacetylation of histones plays an important role in the regulation of
gene transcriptions. Histone acetylation is mediated by histone acetyltransferase; the …

Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene.
Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no known effective
pharmacological therapy. The fibroblastic foci of IPF contain activated myofibroblasts that …

In response to environmental cues, enzymes that influence the functions of proteins, through
reversible post-translational modifications supervise the coordination of cell behavior like …