Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

Histone proteins and the nucleosomes they form with DNA are the fundamental building
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …

The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is
known about their function in mammalian development. HDAC1 was implicated previously …

CNRS–INSERM–ULP, BP 163 other studies, the C-terminal histone-fold domains of core
histones have similar conformations that are critical 67404 Illkirch, Strasbourg France for the …

Understanding the function of histone modifications across inducible genes in mammalian
cells requires quantitative, comparative analysis of their fate during gene activation and …

Phosphorylation at a highly conserved serine residue (Ser-10) in the histone H3 tail is
considered to be a crucial event for the onset of mitosis. This modification appears early in …