Many derivatives and analogs of the natural vitamin A compounds have been synthesized,
and some of these retinoids are very active in various bioassays that may be predictive for …

In addition to all-trans-retinoic acid and its 9 and 13-cis isomers, four synthetic retinoids are
currently available to treat diseases of hyperproliferation, such as acne, psoriasis, and …

The reaction of zinc dust with primary or secondary benzylic halides 1 bearing
variousfunctional groups such as an ester, halide, cyano, or even a ketone group, in THF or …

Retinoid signalling pathways are involved in numerous processes in cells, particularly those
mediating differentiation and apoptosis. The endogenous ligands that bind to the retinoid …

2007-05-30 Assigned to DAIICHI SANKYO COMPANY, LIMITED reassignment DAIICHI
SANKYO COMPANY, LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

A series of 15 heteroarotinoids has been prepared and evaluated for activity against
Mycobacterium bovis BCG with the thiourea-containing isoxyl (7)(0.5 μg/mL) as the …

The anti-cancer activities and toxicities of retinoic acid (RA) and synthetic retinoids are
mediated through nuclear RA receptors (RARs) and retinoid X receptors (RXRs) that act as …

A series of retinoids, containing heteroatoms in a cyclic ring and called heteroarotinoids,
were synthesized, and their biological activity was evaluated using tissue culture lines that …

In a search for retinoic acid receptor (RAR and RXR)-selective ligands, a series of isoxazole
retinoids was synthesized and evaluated in vitro in transcriptional activation and competition …

Retinoic acid (RA) and its synthetic analogues, retinoids, have shown promising results in
the prevention of epithelial carcinogenesis and in the treatment of acute promyelocytic …