Infectious and parasitic diseases generate large economic losses in salmon farming. A
feasible and sustainable alternative to prevent disease outbreaks may be represented by …

The rainbow trout (Oncorhynchus mykiss) is one of the most widely studied of model fish
species. Extensive basic biological information has been collected for this species, which …

Fascinating about classical major histocompatibility complex (MHC) molecules is their
polymorphism. The present study is a review and discussion of the fish MHC situation. The …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

The thymus plays a pivotal role in the development of the adaptive immune system, an
important factor that separates higher vertebrates from the rest of the animal phyla. The …

Abstract Background MHC class I (MHCI) molecules are the key presenters of peptides
generated through the intracellular pathway to CD8-positive T-cells. In fish, MHCI genes …

Studies of the innate immune system have recently shown that, in addition to its role in
producing the primary response that slows down pathogens, it may also play an important …

We have cloned the first CD8α gene from an ectothermic source using a degenerate primer
for Ig superfamily V domains. Similar to homologues in higher vertebrates, the rainbow trout …

Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) represent two salmonid
genera separated for 15–20 million years. cDNA sequences were determined for the …

Interferons are essential for establishing cytotoxic T-lymphocyte immunity against viral
pathogens through different mechanisms including the modulation of antigen presentation to …