Chondroitin sulfate proteoglycans: Structure‐function relationship with implication in neural development and brain disorders

S Avram, S Shaposhnikov, C Buiu… - BioMed research …, 2014 - Wiley Online Library
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components that contain
two structural parts with distinct functions: a protein core and glycosaminoglycan (GAG) side …

Cationic antimicrobial peptides cytotoxicity on mammalian cells: an analysis using therapeutic index integrative concept

M Bacalum, M Radu - International Journal of Peptide Research and …, 2015 - Springer
Antimicrobial peptides (AMPs) represent a class of molecules synthesized by different
organisms as an ancient innate defense mechanism against different pathogens like …

A brief overview of antimicrobial peptides containing unnatural amino acids and ligand-based approaches for peptide ligands

JB Bhonsle, T Clark, L Bartolotti… - Current Topics in …, 2013 - ingentaconnect.com
Antimicrobial Peptides (AMPs) incorporating unnatural Amino Acids have several
advantages over naturally occurring AMPs based on factors such as bioavailability …

[HTML][HTML] Improving short antimicrobial peptides despite elusive rules for activity

R Mikut, S Ruden, M Reischl, F Breitling… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Antimicrobial peptides (AMPs) can effectively kill a broad range of life threatening multidrug-
resistant bacteria, a serious threat to public health worldwide. However, despite great hopes …

QSAR modeling of the antimicrobial activity of peptides as a mathematical function of a sequence of amino acids

MA Toropova, AM Veselinović, JB Veselinović… - … Biology and Chemistry, 2015 - Elsevier
Antimicrobial peptides have emerged as new therapeutic agents for fighting multi-drug-
resistant bacteria. However, the process of optimizing peptide antimicrobial activity and …

Multispecies activity screening of microcin J25 mutants yields antimicrobials with increased specificity toward pathogenic Salmonella species relative to human …

SC Ritter, ML Yang, YN Kaznessis… - Biotechnology and …, 2018 - Wiley Online Library
Modern large‐scale agricultural practices that incorporate high density farming with
subtherapeutic antibiotic dosing are considered a major contributor to the rise of antibiotic …

Implications of Biomaterials for Chronic Wounds

VS Barbu, MD Gaboreanu, IC Marinas… - Mini-Reviews in …, 2025 - benthamdirect.com
The use of biomaterials in treating and managing chronic wounds represents a significant
challenge in global healthcare due to the complex nature of these wounds, which are slow …

Machine learning in the rational design of antimicrobial peptides

P Rondon-Villarreal, DA Sierra… - Current Computer-Aided …, 2014 - ingentaconnect.com
One of the most important public health issues is the microbial and bacterial resistance to
conventional antibiotics by pathogen microorganisms. In recent years, many researches …

The cationic tetradecapeptide mastoparan as a privileged structure for drug discovery: Enhanced antimicrobial properties of mitoparan analogues modified at position …

J Howl, L Howl, S Jones - Peptides, 2018 - Elsevier
Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory
response post envenomation. Most endogenous MPs share common structural elements …

Natural compounds therapeutic features in brain disorders by experimental, bioinformatics and cheminformatics methods

S Avram, A Puia, AM Udrea… - Current Medicinal …, 2020 - benthamdirect.com
Background: Synthetic compounds with pharmaceutical applications in brain disorders are
daily designed and synthesized, with well first effects but also seldom severe side effects …