YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
Sarcomatoid renal cell carcinoma: biology, natural history and management
Sarcomatoid dedifferentiation is an uncommon feature that can occur in most histological
subtypes of renal cell carcinomas (RCCs) and carries a decidedly poor prognosis …
subtypes of renal cell carcinomas (RCCs) and carries a decidedly poor prognosis …
[HTML][HTML] New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia
Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma
Z Bakouny, DA Braun, SA Shukla, W Pan, X Gao… - Nature …, 2021 - nature.com
Sarcomatoid and rhabdoid (S/R) renal cell carcinoma (RCC) are highly aggressive tumors
with limited molecular and clinical characterization. Emerging evidence suggests immune …
with limited molecular and clinical characterization. Emerging evidence suggests immune …
Facts and hopes for immunotherapy in renal cell carcinoma
Immunotherapy has made a significant impact in many tumors, including renal cell
carcinoma (RCC). RCC has been known to be immunoresponsive since the cytokine era of …
carcinoma (RCC). RCC has been known to be immunoresponsive since the cytokine era of …
Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic: NF2: Mutations
We report 8 cases of a distinctive, previously undescribed renal cell carcinoma associated
with somatic mutations in the neurofibromin 2 (NF2) gene. All patients were adults, ranging …
with somatic mutations in the neurofibromin 2 (NF2) gene. All patients were adults, ranging …
The molecular characteristics of non-clear cell renal cell carcinoma: what's the story morning glory?
A Marchetti, M Rosellini, V Mollica, A Rizzo… - International Journal of …, 2021 - mdpi.com
Non-clear cell renal cell carcinomas are a miscellaneous group of tumors that include
different histological subtypes, each one characterized by peculiarity in terms of genetic …
different histological subtypes, each one characterized by peculiarity in terms of genetic …
The significance of sarcomatoid and rhabdoid dedifferentiation in renal cell carcinoma
Dedifferentiation in renal cell carcinoma (RCC), either sarcomatoid or rhabdoid, is an
infrequent event that may occur heterogeneously in the setting of any RCC histology and is …
infrequent event that may occur heterogeneously in the setting of any RCC histology and is …
Sarcomatoid and rhabdoid renal cell carcinoma: clinical, pathologic, and molecular genetic features
AJ Adeniran, B Shuch… - The American Journal of …, 2024 - journals.lww.com
Renal cell carcinoma (RCC) with sarcomatoid and rhabdoid morphologies has an
aggressive biological behavior and a typically poor prognosis. The current 2022 WHO …
aggressive biological behavior and a typically poor prognosis. The current 2022 WHO …
Genetic alterations in renal cancers: Identification of the mechanisms underlying cancer initiation and progression and of therapeutic targets
Renal cell cancer (RCC) involves three most recurrent sporadic types: clear-cell RCC (70–
75%, CCRCC), papillary RCCC (10–15%, PRCC), and chromophobe RCC (5%, CHRCC) …
75%, CCRCC), papillary RCCC (10–15%, PRCC), and chromophobe RCC (5%, CHRCC) …