YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

Sarcomatoid renal cell carcinoma: biology, natural history and management

KA Blum, S Gupta, SK Tickoo, TA Chan… - Nature Reviews …, 2020 - nature.com
Sarcomatoid dedifferentiation is an uncommon feature that can occur in most histological
subtypes of renal cell carcinomas (RCCs) and carries a decidedly poor prognosis …

[HTML][HTML] New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia

K Trpkov, O Hes, SR Williamson, AJ Adeniran… - Modern Pathology, 2021 - Elsevier
Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma

Z Bakouny, DA Braun, SA Shukla, W Pan, X Gao… - Nature …, 2021 - nature.com
Sarcomatoid and rhabdoid (S/R) renal cell carcinoma (RCC) are highly aggressive tumors
with limited molecular and clinical characterization. Emerging evidence suggests immune …

Facts and hopes for immunotherapy in renal cell carcinoma

C Yao, T Zhang, T Wu, J Brugarolas - Clinical Cancer Research, 2022 - AACR
Immunotherapy has made a significant impact in many tumors, including renal cell
carcinoma (RCC). RCC has been known to be immunoresponsive since the cytokine era of …

Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic: NF2: Mutations

P Argani, VE Reuter, JN Eble, L Vlatkovic… - The American journal …, 2020 - journals.lww.com
We report 8 cases of a distinctive, previously undescribed renal cell carcinoma associated
with somatic mutations in the neurofibromin 2 (NF2) gene. All patients were adults, ranging …

The molecular characteristics of non-clear cell renal cell carcinoma: what's the story morning glory?

A Marchetti, M Rosellini, V Mollica, A Rizzo… - International Journal of …, 2021 - mdpi.com
Non-clear cell renal cell carcinomas are a miscellaneous group of tumors that include
different histological subtypes, each one characterized by peculiarity in terms of genetic …

The significance of sarcomatoid and rhabdoid dedifferentiation in renal cell carcinoma

AW Hahn, J Lebenthal, G Genovese, K Sircar… - Cancer Treatment and …, 2022 - Elsevier
Dedifferentiation in renal cell carcinoma (RCC), either sarcomatoid or rhabdoid, is an
infrequent event that may occur heterogeneously in the setting of any RCC histology and is …

Sarcomatoid and rhabdoid renal cell carcinoma: clinical, pathologic, and molecular genetic features

AJ Adeniran, B Shuch… - The American Journal of …, 2024 - journals.lww.com
Renal cell carcinoma (RCC) with sarcomatoid and rhabdoid morphologies has an
aggressive biological behavior and a typically poor prognosis. The current 2022 WHO …

Genetic alterations in renal cancers: Identification of the mechanisms underlying cancer initiation and progression and of therapeutic targets

U Testa, E Pelosi, G Castelli - Medicines, 2020 - mdpi.com
Renal cell cancer (RCC) involves three most recurrent sporadic types: clear-cell RCC (70–
75%, CCRCC), papillary RCCC (10–15%, PRCC), and chromophobe RCC (5%, CHRCC) …