An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …

Molecular hybridization is a new concept in drug design and development based on the
combination of pharmacophoric moieties of different bioactive substances to produce a new …

The quinoline ring system1-5 is present in a number of natural6 and synthetic products often
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …

Multifunctional compounds (MFCs) are designed broadly as hybrid or conjugated drugs or
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …

Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

In this article the design of hybrid molecules that covalently connect two distinct drug entities
in one molecule, at least one part being a biologically active natural product will be …

Several new 12-amino-6, 7, 10, 11-tetrahydro-7, 11-methanocycloocta [b] quinoline
derivatives (tacrine− huperzine A hybrids, huprines) have been synthesized and tested as …

In this study, we attempted to derive a comprehensive SAR picture for the class of
acetylcholinesterase (AChE) inhibitors related to tacrine, a drug currently in use for the …

Conspectus The enzyme acetylcholinesterase (AChE) hydrolyzes the neurotransmitter
acetylcholine (ACh) at cholinergic synapses of the peripheral and central nervous system …