The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …

The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action
potential repolarization, effectively controlling the QT interval of the electrocardiogram …

Kv1. 3 channels regulate proliferation of normal lymphocytes, but the role of voltage-gated
potassium channels in transformed hematopoietic cells is not known. We examined …

Unintended block of HERG K+ channels is a side effect of many common medications and is
the most common cause of acquired long QT syndrome associated with increased risk of life …

The molecular mechanisms underlying congenital long QT syndrome (LQTS) are now
beginning to be understood. New insights into the etiology and therapeutic strategies are …

Mammalian ether‐à‐go‐go (EAG) channels are voltage‐gated K+ channels. They are
encoded by the KCNH gene family and divided into three subfamilies, eag (Kv10), erg (eag …

Cardiac I Kr is a critical repolarizing current in the heart and a target for inherited and
acquired long-QT syndrome (LQTS). Biochemical and functional studies have demonstrated …