The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
JE Darnell Jr, M Kerr, GR Stark - Science, 1994 - science.org
Through the study of transcriptional activation in response to interferon α (IFN-α) and
interferon γ (IFN-γ), a previously unrecognized direct signal transduction pathway to the …
interferon γ (IFN-γ), a previously unrecognized direct signal transduction pathway to the …
[HTML][HTML] Mutations associated with acquired resistance to PD-1 blockade in melanoma
Background Approximately 75% of objective responses to anti–programmed death 1 (PD-1)
therapy in patients with melanoma are durable, lasting for years, but delayed relapses have …
therapy in patients with melanoma are durable, lasting for years, but delayed relapses have …
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations
Loss-of-function mutations in JAK1/2 can lead to acquired resistance to anti-programmed
death protein 1 (PD-1) therapy. We reasoned that they may also be involved in primary …
death protein 1 (PD-1) therapy. We reasoned that they may also be involved in primary …
Interferon-γ: an overview of signals, mechanisms and functions
Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …
transcriptional regulation of immunologically relevant genes. This article reviews the current …
The JAK-STAT pathway at twenty
GR Stark, JE Darnell - Immunity, 2012 - cell.com
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the
transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I …
transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I …
Jaks and STATs: biological implications
▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …
a wide array of cellular functions in the lympho-hematopoietic system. These factors …
Protein modules and signalling networks
T Pawson - Nature, 1995 - nature.com
Communication between cells assumes particular importance in multicellular organisms.
The growth, migration and differentiation of cells in the embryo, and their organization into …
The growth, migration and differentiation of cells in the embryo, and their organization into …
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK–STAT signaling pathway
The JAK–STAT signaling pathway has been implicated in mediating biologic responses
induced by many cytokines. However, cytokines that promote distinct cellular responses …
induced by many cytokines. However, cytokines that promote distinct cellular responses …
[HTML][HTML] Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
The STAT1 transcription factor is activated in response to many cytokines and growth
factors. To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in …
factors. To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in …