Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer,
accounting for 85% to 90% of all liver cancer cases. It is a hepatocyte-derived primary tumor …

Lipids play essential roles in the cell as components of cellular membranes, signaling
molecules, and energy storage sources. Lipid droplets are cellular organelles composed of …

There is considerable heterogeneity in the cardiometabolic abnormalities associated with
obesity. We evaluated multi-organ system metabolic function in 20 adults with metabolically …

Mitochondria are critical for proper organ function and mechanisms to promote
mitochondrial health during regeneration would benefit tissue homeostasis. We report that …

Abstract Changes in protein turnover play an important role in dynamic physiological
processes, including skeletal muscle regeneration, which occurs as an essential part of …

Age is a risk factor for numerous diseases, including neurodegenerative diseases, cancers,
and diabetes. Loss of protein homeostasis is a central hallmark of aging. Activation of the …

The mammary glands of dairy cows with ketosis face unique challenges, including the
supraphysiological circulating concentrations of free fatty acids (FFA) and apoptosis of …

The response to acute myotoxic injury requires stimulation of local repair mechanisms in the
damaged tissue. However, satellite cells in muscle distant from acute injury have been …

The unfolded protein response (UPR) is a cellular stress response that is activated when
misfolded proteins accumulate in the endoplasmic reticulum (ER). Regulation of the UPR …

Background/Objectives: AMPylation is a post-translational modification involving the transfer
of adenosine monophosphate (AMP) from adenosine triphosphate (ATP) to target proteins …