It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Our physiology and behavior follow precise daily programs that adapt us to the alternating
opportunities and challenges of day and night. Under experimental isolation, these rhythms …

A comprehensive characterization of regulatory elements in the chicken genome across
tissues will have substantial impacts on both fundamental and applied research. Here, we …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

Nuclear receptor corepressors (NCoRs) function in multiprotein complexes containing
histone deacetylase 3 (HDAC3) to alter transcriptional output primarily through repressive …

In sepsis, limited food intake and increased energy expenditure induce a starvation
response, which is compromised by a quick decline in the expression of hepatic PPARα, a …

Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating
metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis …

Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly
expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target …

Glucocorticoids are essential hormones produced by the adrenal cortex with prominent
circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis …

Hepatocyte nuclear factor 4A (HNF4A/NR2a1), a transcriptional regulator of hepatocyte
identity, controls genes that are crucial for liver functions, primarily through binding to …