Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The …

The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

Drug combinations can expand options for antibacterial therapies but have not been
systematically tested in Gram-positive species. We profiled~ 8,000 combinations of 65 …

Sepsis is a complex syndrome with a high incidence, increasing by 8.7% annually over the
last 20 years. Coagulopathy is a leading factor associated with mortality in patients with …

Importance Platelets represent a potential therapeutic target for improved clinical outcomes
in patients with COVID-19. Objective To evaluate the benefits and risks of adding a P2Y12 …

Infective endocarditis is a life‐threatening and enigmatic disease with a mortality of 30% and
a pathophysiology that is poorly understood. However, at its core, an endocarditis lesion is …

In recent years, due to the dramatic increase in and global spread of bacterial resistance to a
number of commonly used antibacterial agents, many studies have been directed at …

Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic
heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is …

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

Inflammation is a complex pathophysiological process underlying many clinical conditions.
Platelets contribute to the thrombo‐inflammatory response. Platelet P2Y12 receptors amplify …