A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in
the choreography of these processes can lead to aneuploidy or genetic instability, fostering …

Aurora is the name given to a family of highly conserved protein kinases with essential roles
in many aspects of cell division. Yeasts have a single Aurora kinase, whereas mammals …

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all
chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as …

Protein kinases have proved to be largely resistant to the design of highly specific inhibitors,
even with the aid of combinatorial chemistry. The lack of these reagents has complicated …

The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis.
Here, we describe ZM447439, a novel selective Aurora kinase inhibitor. Cells treated with …

Kinetochores are macromolecular machines that couple chromosomes to dynamic
microtubule tips during cell division, thereby generating force to segregate the …

The centromere is a chromosomal locus that ensures delivery of one copy of each
chromosome to each daughter at cell division. Efforts to understand the nature and …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

The Aurora kinases are essential for the regulation of chromosome segregation and
cytokinesis during mitosis. Aberrant expression and activity of these kinases occur in a wide …