FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …

Jun N-terminal kinases or JNKs have been shown to be involved in a wide array of signaling
events underlying tumorigenesis and tumor progression. Through its interaction with a …

Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization.
This pathway maintains nutrients levels for vital cellular functions during periods of …

Macroautophagy is a major intracellular degradation process recognized as playing a
central role in cell survival and longevity. This multistep process is extensively regulated at …

Autophagy is finely regulated at multiple levels and plays crucial roles in development and
disease. In the fat body of the silkworm, Bombyx mori, autophagy occurs and Atg gene …

Mounting evidence shows that selenium possesses chemotherapeutic potential against
tumor cells, including leukemia, prostate cancer and colorectal cancer (CRC) cells …

Macroautophagy, usually referred to as autophagy, is a degradative pathway wherein
cytoplasmatic components such as aggregated/misfolded proteins and organelles are …

ADAM17 and its inhibitor TIMP3 are involved in nephropathy, but their role in diabetic kidney
disease (DKD) is unclear. Diabetic Timp3−/− mice showed increased albuminuria …

Simple Summary Autophagy is a dynamic and tightly regulated process that seems to have
dual effects in cancer. In some contexts, it can induce carcinogenesis and promote cancer …

Glycogen synthase kinase-3 (GSK-3) is a critical enzyme which participates in a complex
array of important cellular processes and is often involved in various human diseases. It was …