Polymer nano-systems for the encapsulation and delivery of active biomacromolecular therapeutic agents

M Machtakova, H Thérien-Aubin… - Chemical society …, 2022 - pubs.rsc.org
Biomacromolecular therapeutic agents, particularly proteins, antigens, enzymes, and nucleic
acids are emerging as powerful candidates for the treatment of various diseases and the …

Multifunctional scaffolds and synergistic strategies in tissue engineering and regenerative medicine

N Muzzio, S Moya, G Romero - Pharmaceutics, 2021 - mdpi.com
The increasing demand for organ replacements in a growing world with an aging population
as well as the loss of tissues and organs due to congenital defects, trauma and diseases has …

Smart nanoparticles for chemo-based combinational therapy

B Shrestha, L Wang, EM Brey, GR Uribe, L Tang - Pharmaceutics, 2021 - mdpi.com
Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated
with low therapeutic index, acquired resistance, and various adverse effects. With the …

Nanocarriers with multiple cargo load—a comprehensive preparation guideline using orthogonal strategies

N Hueppe, FR Wurm… - Macromolecular rapid …, 2023 - Wiley Online Library
Multifunctional nanocarriers enhance the treatment efficacy for modern therapeutics and
have gained increasing importance in biomedical research. Codelivery of multiple bioactive …

[HTML][HTML] Polypeptide-based multilayer nanoarchitectures: Controlled assembly on planar and colloidal substrates for biomedical applications

MA Motta, L Mulko, E Marin, A Larrañaga… - Advances in Colloid and …, 2024 - Elsevier
Polypeptides have shown an excellent potential in nanomedicine thanks to their
biocompatibility, biodegradability, high functionality, and responsiveness to several stimuli …

Layer-by-Layer technique as a versatile tool for gene delivery applications

DS Linnik, YV Tarakanchikova, MV Zyuzin… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Gene therapy is a breakthrough medical field which focuses on the therapeutic
delivery of recombinant nucleic acids in order to treat or prevent a broad spectrum of …

Interplay of the assembly conditions on drug transport mechanisms in polyelectrolyte multilayer films

RA Bataglioli, JBM Rocha Neto, BS Leão… - Langmuir, 2020 - ACS Publications
The layer-by-layer film deposition is a suitable strategy for the design and functionalization
of drug carriers with superior performance, which still lacks information describing the …

Poly(β-amino ester) Nanoparticles Modified with a Rabies-Virus-Derived Peptide for the Delivery of ASCL1 across a 3D In Vitro Model of the Blood–Brain Barrier

TM Rodgers, N Muzzio, A Valero, I Ahmad… - ACS applied nano …, 2023 - ACS Publications
Gene editing has emerged as a therapeutic approach to manipulate the genome for killing
cancer cells, protecting healthy tissues, and improving immune response to a tumor. The …

A comparative QCM-D study for various drug sorption behaviors and chemical degradation of chitosan/PAA LbL multilayered films

D Yilmaz-Aykut, O Yolacan, H Deligoz - Journal of Polymer Research, 2023 - Springer
In the study, the loading and desorption properties of four different drug models, namely
ibuprofen sodium (IBFNa), diclofenac sodium (DCFNa), gentamicin sulfate (GS), and …

Stabilization of poly (β-Amino Ester) nanoparticles for the efficient intracellular delivery of piggybac transposon

T Rodgers, N Muzzio, C Watson, G Romero - Bioengineering, 2021 - mdpi.com
The administration of gene-editing tools has been proposed as a promising therapeutic
approach for correcting mutations that cause diseases. Gene-editing tools, composed of …