The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism

LY Tian, DJ Smit, M Jücker - International journal of molecular sciences, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives

X Shi, X Wang, W Yao, D Shi, X Shao, Z Lu… - Signal transduction and …, 2024 - nature.com
Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …

MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression

Y Fu, B Mackowiak, D Feng, H Lu, Y Guan, T Lehner… - Gut, 2023 - gut.bmj.com
Objective The current treatment for hepatocellular carcinoma (HCC) to block angiogenesis
and immunosuppression provides some benefits only for a subset of patients with HCC, thus …

[HTML][HTML] An immune and epigenetics-related scoring model and drug candidate prediction for hepatic carcinogenesis via dynamic network biomarker analysis and …

Y Hu, X Zhang, Q Li, Q Zhou, D Fang, Y Lu - Computational and Structural …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a malignant tumor with high mortality. This study aimed
to build a prognostic signature for HCC patients based on immune-related genes (IRGs) and …

[HTML][HTML] The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting

CY Huang - International Journal of Molecular Sciences, 2025 - mdpi.com
Dihydroorotase (DHOase; EC 3.5. 2.3) is a zinc-dependent metalloenzyme that plays a key
role in the de novo pyrimidine biosynthesis pathway, catalyzing the reversible cyclization of …

Construction of diagnostic models for the progression of hepatocellular carcinoma using machine learning

X Jiang, R Zhou, F Jiang, Y Yan, Z Zhang… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Liver cancer is one of the most prevalent forms of cancer worldwide. A significant proportion
of patients with hepatocellular carcinoma (HCC) are diagnosed at advanced stages, leading …

[HTML][HTML] Alternative splicing of transposable elements in human breast cancer

A Nesta, DFT Veiga, J Banchereau, O Anczukow… - Mobile …, 2025 - pmc.ncbi.nlm.nih.gov
Transposable elements (TEs) drive genome evolution and can affect gene expression
through diverse mechanisms. In breast cancer, disrupted regulation of TE sequences may …

Alterations in serum metabolic profiles of early-stage hepatocellular carcinoma patients after radiofrequency ablation therapy

F Zhang, J Wu, L Zhang, J Zhang, R Yang - Journal of Pharmaceutical and …, 2024 - Elsevier
Objective To investigate the alterations in serum metabolic profiles and early-stage
hepatocellular carcinoma (HCC) patient characteristics after radiofrequency ablation (RFA) …

Prognostic significance of pyrimidine metabolism-related genes as risk biomarkers in hepatocellular carcinoma

J Lu, L Shi, C Zhang, F Zhang, M Cai - Journal of Chemotherapy, 2024 - Taylor & Francis
Hepatocellular carcinoma (HCC), as a malignancy derived from liver tissue, is typically
associated with poor prognosis. Increasing evidence suggests a connection between …

Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma

S Tang, H Chen - Journal of Environmental Pathology …, 2024 - dl.begellhouse.com
Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with significant heterogeneity,
which poses challenges in predicting prognosis and treatment outcomes. The impact of iron …