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The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives
X Shi, X Wang, W Yao, D Shi, X Shao, Z Lu… - Signal transduction and …, 2024 - nature.com
Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …
associated mortality. Despite its significance, the mechanisms governing metastasis are not …
MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression
Objective The current treatment for hepatocellular carcinoma (HCC) to block angiogenesis
and immunosuppression provides some benefits only for a subset of patients with HCC, thus …
and immunosuppression provides some benefits only for a subset of patients with HCC, thus …
[HTML][HTML] An immune and epigenetics-related scoring model and drug candidate prediction for hepatic carcinogenesis via dynamic network biomarker analysis and …
Y Hu, X Zhang, Q Li, Q Zhou, D Fang, Y Lu - Computational and Structural …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a malignant tumor with high mortality. This study aimed
to build a prognostic signature for HCC patients based on immune-related genes (IRGs) and …
to build a prognostic signature for HCC patients based on immune-related genes (IRGs) and …
[HTML][HTML] The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting
CY Huang - International Journal of Molecular Sciences, 2025 - mdpi.com
Dihydroorotase (DHOase; EC 3.5. 2.3) is a zinc-dependent metalloenzyme that plays a key
role in the de novo pyrimidine biosynthesis pathway, catalyzing the reversible cyclization of …
role in the de novo pyrimidine biosynthesis pathway, catalyzing the reversible cyclization of …
Construction of diagnostic models for the progression of hepatocellular carcinoma using machine learning
X Jiang, R Zhou, F Jiang, Y Yan, Z Zhang… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Liver cancer is one of the most prevalent forms of cancer worldwide. A significant proportion
of patients with hepatocellular carcinoma (HCC) are diagnosed at advanced stages, leading …
of patients with hepatocellular carcinoma (HCC) are diagnosed at advanced stages, leading …
[HTML][HTML] Alternative splicing of transposable elements in human breast cancer
Transposable elements (TEs) drive genome evolution and can affect gene expression
through diverse mechanisms. In breast cancer, disrupted regulation of TE sequences may …
through diverse mechanisms. In breast cancer, disrupted regulation of TE sequences may …
Alterations in serum metabolic profiles of early-stage hepatocellular carcinoma patients after radiofrequency ablation therapy
F Zhang, J Wu, L Zhang, J Zhang, R Yang - Journal of Pharmaceutical and …, 2024 - Elsevier
Objective To investigate the alterations in serum metabolic profiles and early-stage
hepatocellular carcinoma (HCC) patient characteristics after radiofrequency ablation (RFA) …
hepatocellular carcinoma (HCC) patient characteristics after radiofrequency ablation (RFA) …
Prognostic significance of pyrimidine metabolism-related genes as risk biomarkers in hepatocellular carcinoma
J Lu, L Shi, C Zhang, F Zhang, M Cai - Journal of Chemotherapy, 2024 - Taylor & Francis
Hepatocellular carcinoma (HCC), as a malignancy derived from liver tissue, is typically
associated with poor prognosis. Increasing evidence suggests a connection between …
associated with poor prognosis. Increasing evidence suggests a connection between …
Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma
S Tang, H Chen - Journal of Environmental Pathology …, 2024 - dl.begellhouse.com
Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with significant heterogeneity,
which poses challenges in predicting prognosis and treatment outcomes. The impact of iron …
which poses challenges in predicting prognosis and treatment outcomes. The impact of iron …