The past, present and future of anti-malarial medicines

EG Tse, M Korsik, MH Todd - Malaria journal, 2019 - Springer
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis

M Zhang, C Wang, TD Otto, J Oberstaller, X Liao… - Science, 2018 - science.org
INTRODUCTION Malaria remains a devastating global parasitic disease, with the majority of
malaria deaths caused by the highly virulent Plasmodium falciparum. The extreme AT-bias …

Rapid, selective heavy metal removal from water by a metal–organic framework/polydopamine composite

DT Sun, L Peng, WS Reeder, SM Moosavi… - ACS central …, 2018 - ACS Publications
Drinking water contamination with heavy metals, particularly lead, is a persistent problem
worldwide with grave public health consequences. Existing purification methods often …

[KIRJA][B] Neosporosis in animals

JP Dubey, A Hemphill, R Calero-Bernal, G Schares - 2017 - taylorfrancis.com
Key features: Written by the scientist who named this parasite and was the first to set up
proper diagnostic techniques Serves as the first ever book to provide information on the …

[HTML][HTML] Open science approaches to COVID-19

GT Edwin, DM Klug, MH Todd - F1000Research, 2020 - ncbi.nlm.nih.gov
In only a matter of months, the coronavirus disease of 2019 (COVID-19) has spread around
the world. The global impact of the disease has caused significant and repeated calls for …

Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: compounds and therapeutic targets

M Siles-Lucas, A Casulli, R Cirilli… - PLoS neglected tropical …, 2018 - journals.plos.org
Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by
infections with the larval stages of the cestode parasites Echinococcus granulosus and E …

Current screening methodologies in drug discovery for selected human diseases

OM Lage, MC Ramos, R Calisto, E Almeida… - Marine drugs, 2018 - mdpi.com
The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

[HTML][HTML] There is no market for new antibiotics: this allows an open approach to research and development

DM Klug, FIM Idiris, MAT Blaskovich… - Wellcome open …, 2021 - ncbi.nlm.nih.gov
There is an increasingly urgent need for new antibiotics, yet there is a significant and
persistent economic problem when it comes to develo** such medicines. The problem …

Bioinformatics in translational drug discovery

SK Wooller, G Benstead-Hume, X Chen, Y Ali… - Bioscience …, 2017 - portlandpress.com
Bioinformatics approaches are becoming ever more essential in translational drug discovery
both in academia and within the pharmaceutical industry. Computational exploitation of the …