Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

The number of protein-based drugs is exponentially increasing. However, development of
protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic …

Scorpion toxins have been central to the investigation and understanding of the
physiological role of potassium (K+) channels and their expansive function in membrane …

Malignant glioma is one of the most untreatable cancers because of the formidable blood-
brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors …

The recent elucidation of molecular regulators of apoptosis and their roles in cellular
oncogenesis has motivated the development of biomacromolecular anticancer therapeutics …

The viability of large-scale industrial production of recombinant biomolecules of
pharmaceutical interest significantly depends on the separation and purification techniques …

It is an attractive strategy to develop a recombinant bacterial vector vaccine by expressing
exogenous protective antigen to induce the immune response, and the main concern is how …

Synthetic subunit vaccines hold great promise to prevent infectious diseases, but they often
induce only weak immune responses. Here bioengineering techniques to develop …

Background Protein transduction is safer than viral vector-mediated transduction for the
delivery of a therapeutic protein into a cell. Fusion proteins with an arginine-rich cell …

Microbial transglutaminase (MTG) from Streptomyces is naturally secreted as a zymogen
(pro-MTG), which is then activated by the removal of its N-terminal proregion by additional …