Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

The ProTide technology is a prodrug approach developed for the efficient intracellular
delivery of nucleoside analogue monophosphates and monophosphonates. In this …

Simple Summary In this review, the authors propose a crosswise examination of cytarabine-
related issues ranging from the spectrum of clinical activity and severe toxicities, through …

Gemcitabine is an antimetabolite ranking among the most prescribed anticancer drugs
worldwide. This nucleoside analog exerts its antiproliferative action after tumoral conversion …

Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs
that, starting from the small field of paediatric oncology, in combination with other …

Non-Hodgkin lymphomas (NHL) are lymphoid tumors that arise by a complex process of
malignant transformation of mature lymphocytes during various stages of differentiation. The …

The inter-individual differences in cancer susceptibility are somehow correlated with the
genetic differences that are caused by the polymorphisms. These genetic variations in drug …

Metabolic rewiring and cellular reprogramming are trademarks of neoplastic initiation and
progression in acute myeloid leukemia (AML). Metabolic alteration in leukemic cells is often …

Introduction: Nucleosidic analogs such as pyrimidine and purine derivatives are mainstay in
the field of treating cancers, both in adults and in children. All these drugs act as …

Adverse reactions to capecitabine-based chemotherapy limit full administration of cytotoxic
agents. Likewise, genetic variations associated with capecitabine-related adverse reactions …